Latest Drugwonks' Blog

Lot's of high-fives about the record number of approvals coming out of FDA.   Not to be a buzz kill but who cares unless patients are nickled and dimed to death by the intellectually empty barking of health plan and pharmacy benefit management firms that to use new treatments is simply allowing drug companies to rake in unjust profits that will bankrupt America and drive premiums sky high.  

In particular AHIP, the AHIP funded sock puppet called the National Coalition on Health Care and Express Scripts have been feeding the media beasts scare stories of greedy Big Pharma and their high prices forcing health systems to ration care.   In the wake of all the new drug approvals (and the FDA is still too damn slow) anticipate the next wave of articles about "How Can We Afford All These Drugs?"

The fact is, new medicines are developed not to save health plans money.  They do by replacing sick hospitalizaed patients with healthy productive comsumers and premium payers.  But new medicines -- especially this generation of drugs and the next -- are developed to predict, and prevent diseases from progressing by using what Eric Topol and Stephen Quake called molecluar stethoscopes:  chips and high powered computers that can detect and sequence the gene expression networks impllicated in disease or disease risk in real time.  That will lead to more precise answers about how to prevent and how to treat disease.  And it will lead to an acceleration of drug development and to determining with nearly 100 percent accuracy what works.

The AHIPs and Express Scripts of the world, as well as most hospitals (at least in the US) are seeing their business model crumble.  They don't know it yet, anymore than the record companies and movie chains and department stores had the foresight to anticipate how digitization of information would force them to the brink of extinction.   It's happening to the big box approach to health care.   And the rent seekers and businesses that will be destroyed are panicking.  

The only ways they have left to defend the status quo is lobbying, regulations and scaring the public.  And they will fight like hell to limit access to new, targeted treatments that deliver most of the economic and social benefits to indivudals.   WIth a willing and biased media behind them, they will have some initial success.  But soon the winds of change will sweep them and their pre-industrial approach to managing care will away.  

We are on the edge of the Cure Century and they hate it.  

In case you missed this story over the holidays.

WASHINGTON (AP) -- The Food and Drug Administration approved 41 first-of-a-kind drugs in 2014, including a record number of medicines for rare diseases, pushing the agency's annual tally of drug approvals to its highest level in 18 years. FDA drug approvals are considered a barometer of industry innovation and the federal government's efficiency in reviewing new therapies. Last year's total was the most since the all-time high of 53 drugs approved in 1996.

The 2014 approval list includes 15 drugs for so-called orphan diseases, which are rare conditions and disorders that affect fewer than 200,000 people in the U.S. Last year's tally, which included drugs for rare cancer and metabolic disorders, exceeded the 13 orphan drugs approved in 2012.

Nine drug approvals in 2014 benefited from the FDA's "breakthrough" designation, a recent program designed to speed up development of promising drugs by providing companies with extra meetings and earlier communication with FDA scientists. Milne said these meetings provide more predictability and transparency about the FDA review process, a boon to both companies and investors.

The complete AP story can be found here.

12 Years a Slave

  • 01.04.2015
It's been a dozen years since the nefarious Andrew Wakefield article. Will the truth really set us free.

Have a look at this video and please pass it on.
A plaque at the entrance of the American Civilization Center at Brandeis University proclaims:  “To speak freely, to question openly, to differ without fear.”

That plaque has been tarnished by the unwillingness of Brandeis University to live up to that credo.   Rather than immediately defend Brandeis student Daniel Mael’s right to republish a fellow student's call for intifada in America and her lack of remorse over  of the death of the two NYPD officers, Brandeis has let radical forces threaten Mael’s safety. 

As Lori Lowenthal Marcus wrote: “There’s an ugly tempest brewing at Brandeis University and it’s based, at least in part, on free speech, tolerance and student safety. The storm grew out of a more generalized anger with the state of public discourse and of the safety of individuals in our society at large.

But at this point, one black self-described revolutionary and one Jewish conservative journalist, both Brandeis students, are the figureheads in a battle for the soul of an institution.”

That battle was lost long ago.  Brandeis, like many other universities now limit the actions and speech of anyone who differ with those groups who define themselves as oppressed or as defending the oppressed.   

Like many other students, Kadijah Lynch is embracing a radical, wholesale attack on America’s democratic capitalism that begins with limiting the freedom of those who disagree with you or dare to criticize you and ends with those that are ‘oppressed’ deciding what the oppressors can do.    

To the radical, suppression of free speech is necessary if the society is unjust and unequal.   The ruling classes and its apologists will use political freedoms and civil liberties to stay in power.   And anyone who disagrees with any aspect of the program or worldview is regarded as a threat to revolution.  Hell, freedom is simply a bourgeois prejudice, as Lenin put it.

So attacking Daniel Mael for reposting ugly Tweets from a fellow student and self-styled revolutionary is not wrong, it’s moral.  

And Brandeis University – or at least a significant share of the administrators, professors and students feel the same way.

Some would point to the University’s invitation to have Jimmy Carter speak about the evils of Israel and dis-honoring Ali Al-Hirsi because she had spoken about the evils of radical Islam as examples of this allegiance to a radical form of egalitarianism.   Indeed, bashing Israel and defending Islam is the most common way to demonstrate support for ‘the oppressed.’   That explains why the anti-police forces have drawn the attention of ISIS, Al Qaeda and why the social media mob attacking Mael is led by the Hamas campus organization, Students for Justice in Palestine

Brandeis not only practices a form of ‘free speech’ that encourages such groups, it is the fountainhead of what Herbert Marcuse – one of its former professors – called repressive tolerance. 

Marcuse believed that in America freedom perpetuates injustice.  In 1965, while still at Brandeis, he wrote a highly influential article entitled, "Repressive Tolerance“ As a Wikipedia article on Marcuse argues that “genuine tolerance does not permit support for "repression", since doing so ensures that marginalized voices will remain unheard. He characterizes tolerance of repressive speech as "inauthentic." Instead, he advocates a form of tolerance that is intolerant of right wing political movements.  That is, the liberation of the oppressed requires silencing those who oppose them.  As Marcuse asserts:

“This means that the ways should not be blocked on which a subversive majority could develop, and if they are blocked by organized repression and indoctrination, their reopening may require apparently undemocratic means. They would include the withdrawal of toleration of speech and assembly from groups and movements which promote aggressive policies, armament, chauvinism, discrimination on the grounds of race and religion, or which oppose the extension of public services, social security, medical care, etc.

As to the scope of this tolerance and intolerance: ... it would extend to the stage of action as well as of discussion and propaganda, of deed as well as of word.”

While teaching at Brandeis, Marcuse was afforded every opportunity to speak his mind.  True his worldview, Marcuse took every chance to criticize those who disagreed with him.   Abraham Sachar, the President of Brandeis who hired Marcuse in 1954 said that Marcuse was “the most relevant symbol in my experience of the cynical radical who demands independence as a right for himself but considers it ‘hypocrisy’ when it is expected of him.”   Sachar goes on to note that Marcuse was not fired for his views but rather quit to accept a longer contract from another university.   Sachar writes that Marcuse never sought to the set the record straight.  Rather, he remained silent. 

Today Brandeis has endorsed the ‘narrative’ of a radical professor being fired for his views.  It recently celebrated Marcuse with a one-day conference entitled: “The Many Dimensions of Herbert Marcuse.”  An ironic title since the event was an intellectual love fest that skated over the discussion of repressive tolerance.  The International Herbert Marcuse Society largely organized the event.  The group consists of diehard radicals who view the organization as an engine of repressive tolerance.  So for instance, the next Society conference focuses on the following question: “ Given Marcuse’s emphasis on praxis, critical pedagogy cannot be limited to classroom space in universities - how can a critical rationality translate into programs of activism, agitation, and organization?”  In other words, how can universities be turned into factories of radicalization and repression?

Marcuse dedicated “Repressive Tolerance” to his students at Brandeis including Angela Davis and Abbie Hoffman.   Davis became closely associated with the Black Panthers, the Communist party and most notoriously, with providing her sawed-off shotgun to kill a judge who had sent her lover, George Jackson, to prison.  She was acquitted and later received the International Lenin Peace Prize (formerly named the International Stalin Peace Prize) by East Germany.  These events have been scrubbed from the official Brandeis University biography of Davis.  

The failure to defend Daniel Mael’s right to republish the vile and violent comments of Ms. Lynch is the result of Brandeis University’s passive acceptance of repressive tolerance.   It is a sad decline.

Sachar recalls that Marcuse and other leftist professors organized a rally at Brandeis during the Cuban Missile Crisis.  They called the Khrushchev-Castro decision to based misses in Cuba as a legitimate response to “American imperialism.”   One speaker, anthropology professor Katherine Gough, declared to wild applause, that if war broke out she hoped America would be defeated. 

When Sachar found out about her comments, her met with her to find out first hand what she said.  Hough repeated her statements.  Sachar told her that he did not “quarrel with her right to denounce American foreign policy. The freedom of platform gave her no warrant for an irresponsible attack.” 

Gough’s husband David Abele (head of the anthropology department) claimed that Sachar’s criticism was illegitimate.  Sachar replied “apparently freedom of speech means that you can dish it out but you don’t have to take it.”  To which Abele said: when I speak it’s my right.  When you speak its intimidation.  Incredibly, Abele then requested a bonus for his wife.  Sachar said no.  Abele and Gough left for another university, but not before suing Brandeis for ‘unfair treatment.’

Sachar did not reward Gough or Abele for their behavior.  His determination to uphold the credo “to speak freely, to question openly, to differ without fear” caused those that attacked that principle to leave Brandeis.

Up till now, the Brandeis community and its president, Fred Lawrence, have failed to defend Daniel Mael and speak out against repressive tolerance.   Next week, when Mael and his parents meet with Lawrence, who is considered to be the front runner to head the Anti-Defamation League.  The president will have a choice:  the valor of Abraham Sachar or Marcuse’ radical program of suppression. 

Baby, it’s cold outside – if you’re suffering from Hep C.

A recent article in the Washington Post, “One company’s battle to stop the wave of high priced drugs,” could more accurately have been titled, “One company’s battle to stop innovation.”

The Post reports:

This week, the country's biggest drug plan manager Express Scripts said it will drop Gilead's drugs Sovaldi and Harvoni from a list of preferred drugs covering 25 million patients and instead will only put Viekira Pak on its list. Express Scripts said it has negotiated a significant discount with AbbVie — perhaps between $20,000 and $30,000 per course of treatment — in return for expanding access to patients and allowing primary care doctors to prescribe the drug … Until recently, Express Scripts didn't exclude any drugs from its list of preferred medications. But the exclusion list grew from 44 drugs two years ago to 66 in this past year.

Until recently, Express Scripts didn't exclude any drugs from its list of preferred medications. But the exclusion list grew from 44 drugs two years ago to 66 in this past year. The company's chief medical officer, Steven Miller, said he's been telegraphing a move like the AbbVie deal all year.

"We need innovation, and affordability has to be part of that innovation," Miller said in an interview. The companies aren't disclosing the discount, but he said the deal helps close the gap between prices in the U.S. and western Europe. Sovaldi is priced at $57,000 in the United Kingdom and $66,000 in Germany.

That’s the party line – for payers. But you have to read on to get the rest of the story -- about the chilling impact the Express Scripts strategy will have on patient care and pharmaceutical innovation.

"The only way you do exclusions," Miller said, "is you have to do drugs that clinically have identical outcomes."

But Dana Goldman, director of the Schaeffer Center for Health Policy and Economics at the University of Southern California, warns this could come at the expense of the patient since not all will respond to the same treatment. Express Scripts says it won't limit access for hepatitis C patients who need Gilead's drugs, but drug exclusions could still be problematic for patients, Goldman said.

"The reality is if you put up barriers for physicians and patients, we know that people won't have as good access," said Goldman, whose own research found that limits on what drug availability lead to worse outcomes for psychosis patients.

What’s really happening is insurers want someone else to pay for their failure to adequately price demand for highly effective, potentially lifesaving drugs. If the critics had their way and new regulations required price slashing, inevitably patients would lose access to lifesaving therapies, both directly and as a result of reduced research and development expenditures on what could be the next Sovaldi, or Ebola-fighting ZMapp.

Insurers also are hardly powerless, which is evident in their ability to shift drug costs to patients. While critics lambaste the American health system as free enterprise run amok, in reality the U.S. health insurance sector is more like a regulated monopoly – with a mandated customer base that will keep growing as Obamacare expands its reach and as America continues to age.

Prescription drugs currently make up just over 11 percent of the nation’s nearly $3 trillion health care tab; simple math indicates pharmaceuticals are not the major driver of runaway U.S. health expenditures.

And Express Scripts is not what anyone would call a disinterested party.

Consider the 2010 comment of George Paz, chairman and chief executive of Express Scripts, “The cheapest drugs is (sic) where we make our profits.” And just who is “cheaper” better for? "Our whole model is switching people to lower-cost drugs. The more money my shareholders make, the more money I make."

Paz ranked sixth on the 2012 Forbes CEO compensation list, with $51.5 million in total compensation the preceding year, and $100.2 million over a five-year period.

More money for George and Co., but less choice and no savings for patients. This has been the case with brand vs. generic medicines for years. But at least these often resulted in lower out-of-pocket co-pay expenses for patients. Today, the same fatten-George’s Wallet schemes are being used for drugs for evermore serious and life-threatening conditions – such as Hep C. Express Scripts enjoys enormous leverage in the marketplace. What Express Script’s Dr. Miller didn't’ say about drug exclusions, is that his employer told investors earlier in the year that company planned to save $1 billion in 2015 by excluding 66 medicines from its list of covered drugs.

And they did.

Brr. That’s the sound of chilling innovation.

One of the myths perpetuated during the debate over the Affordable Care Act (and nowhere more so than in the Michael Moore movie “SiCKO”) was that it would provide “free” health care “like in Europe.”

Such myths die hard – and especially in Vermont.

The Wall Street Journal writes:

Last week, in a reversal that deserves more attention, Democratic Governor Peter Shumlin announced that Vermont would no longer create America’s first statewide single-payer health system. Vermont was seeking a waiver from the Affordable Care Act to abolish what’s left of the nominally private insurance market by 2017, but Mr. Shumlin’s budget gremlins concluded the plan was too expensive and would damage the state economy … The state accountants estimated that his plan required an 11.5% tax on worker payroll, with no exceptions. Individuals, meanwhile, would have paid as much as 9.5% of earnings, which would have applied to everyone making more than four times the poverty level, or $102,220 for a family of four—hardly the 1%. The full $2.59 billion in necessary funding would roughly double current state revenues (about $2.85 billion today).

(The full Wall Street Journal editorial can be found here.)

In other words, there is no such thing as “free” government-supplied health care.

This shouldn’t have come as a surprise. In Canada, while the percentage of taxes used to provide health care varies, it’s estimated that about 22% of taxes collected go into the health system and several provinces, including Quebec, Ontario, Alberta, and British Columbia also charge additional premiums. Citizens in the U.K. pay 11% of each pound they make in weekly income, between £100 and £670 for the NHS,

And what can’t be overlooked is that price controls equals choice controls.

When it comes to the Affordable Care Act, patients can access any medicine they need -- as long as it's on the exchange formulary. Sure, the ACA limits the degree to which insurers can charge higher premiums for sicker patients, but ObamaCare plans found a way around these rules: impose higher out-of-pocket costs for all or most specialty drugs. High co-pays effectively remove choice from the system for many patients.

The breakdown of Silver plans (the most popular category) is particularly revealing. In seven classes of drugs for conditions from cancer to bipolar disorder, more than a fifth of these plans require patients to shoulder 40 percent of the medicine’s cost. And 60 percent of Silver plans place all drugs for illnesses like multiple sclerosis and rheumatoid arthritis in the “formulary tier” with the highest level of cost-sharing.

Nearly every Silver plan across the country, in fact, puts at least one class of drug exclusively in the top cost-sharing tier. In effect, this leaves patients with a given condition — whether HIV or Crohn’s disease — without a single affordable treatment option. Silver is the new Black.

Referring to the Model T, Henry Ford famously said, "Any customer can have a car painted any color that he wants so long as it is black.” That worked out fine – until there was competition. Choice is the great emancipator. The same is true when it comes to healthcare – and a lot more important.

Great article in The Hill...

Improving the Affordable Care Act to help the chronically ill

By Larry Hausner
December 20, 2014
The Hill

This year, one in three Americans chose to forego medical care for themselves or a family member because of cost concerns, according to a new Gallup poll.

The Affordable Care Act was supposed to prevent those situations and extend reasonably priced health care to everyone. But insurance companies have been exploiting loopholes in the law to avoid this obligation.

Fortunately, the Centers for Medicare and Medicaid Services -- the federal agency that regulates health insurance -- recently proposed a new rule that will close such loopholes and strengthen patient protections.

As the organization finalizes its regulations, it has come under pressure from insurance industry lobbyists to water them down. The CMS should resist these efforts and install genuine reforms that will improve health coverage for vulnerable Americans. 

These new regulations take aim at one of the biggest shortcomings of the Affordable Care Act -- unreasonably high patient cost-sharing. The healthcare law caps out-of-pocket expenses at $6,350 for individual plans and $12,700 for family plans. After an insured person or family hits the cap, the insurance company must pay the rest of the treatment costs. 

However, insurers have found a way around that cap by forcing families to pay all the way up to that $12,700 threshold even when only a single household member is sick. The new CMS regulations would prohibit insurance companies from charging more than $6,350 for treating any one patient.

This change protects families and furthers the original principle of the ACA: no one should go bankrupt because of disease.

Insurance companies have also been burdening patients who have qualified for so-called "cost-sharing reduction" plans. These plans feature lower out-of-pocket maximums than standard plans, but are available only to patients earning less than 250 percent of the federal poverty line.

Many of these plans include absurdly high co-insurance rates. A new report by Milliman, a major consulting firm, finds that 22 percent of cost-sharing reduction plans feature co-insurance rates of 50 percent or more for certain specialty drugs. In other words, insurance companies are forcing some of the poorest patients in the country to pay the lion's share of their prescription drug costs.


The new CMS regulations will require insurers to summarize the coverage and benefits for these cost-sharing reduction plans and present that information clearly to customers. That's a welcome move, but the agency could go further by prohibiting insurers from charging poor patients co-insurance at all.

The new rule also addresses the problem of rampant insurer discrimination against some of the most vulnerable Americans -- those suffering from serious diseases like diabetes, cancer, and multiple sclerosis.

A study by Avalere Health, a prominent healthcare advisory company, discovered that an alarming 86 percent of the most common insurance plans sold through the new state-level exchanges placed all medications for at least one drug type in the highest cost-sharing tier. 

In practice, this means that, say, a diabetes patient might be hit with extremely high out-of-pocket expenses when she goes to fill a prescription for key treatments. The Avalere study found that many exchange plans require 30 percent or more "co-insurance" for all diabetes drugs. Co-insurance forces patients to bear a set percentage of the final drug bill, regardless of how big it is. 

In its proposed rule, CMS clarifies that this practice is a form of discrimination against patients. This call-out is commendable but insufficient. The agency should also prohibit companies from pricing all drugs of a particular type out of reach for average patients.

The proposed CMS rule will stop insurers from another method of discrimination -- changing a plan's cost-sharing or benefit structure halfway through the year, after consumers are already locked-in. CMS should also make sure insurers aren’t allowed to drop drug coverage mid-year. 

Finally, the agency's reforms will address a general lack of transparency in insurance plans. Insurers will be required to publish a complete list of covered drugs and their relevant cost-sharing tiers. This change will help patients better understand their plan's coverage and benefits. CMS could further improve transparency by mandating that insurers provide specific cost-sharing information for each drug. 

CMS deserves praise for its newly proposed rule. It will help combat unreasonable cost-sharing arrangements, patient discrimination, and a lack of transparency. With just a few more added patient protections, the agency can ensure that quality health insurance is truly affordable for all.

Hausner is the former CEO of the American Diabetes Association.
We are wired to focus on the rare, visible and dangerous events and then use that information to decide how to act.  Sadly,  those who sowed the wind have reaped the whirlwind of their efforts to use such events to political advantage.  Our civil discourse and our society is always better served by looking at events that stir our emotions from a broader context.   It is always important to check our instinct to use anecdotes that confirm what resonates within us with solid, long term data.  

What do we fear more: guns being used in murder or suicide?   I think the answer is obvious.  And it shapes our behavior, our culture and public policy.  But what is the real risk? 







This gun violence fact is only "startling" because of how the media reinforces the fear of the unseen, outside danger...


We have the tools to speed up development of new innovative medicines.  We just need the will.


December 18, 2014, 02:00 pm
Closing the gap between testing and treatment
The Hill
By John Morrissey

I have just returned from San Francisco and a meeting of more than 20-thousand blood cancer experts at a global hematology conference. I was there as part of  a new mission to rapidly-but-responsibly turn the data from these medical meetings into treatments.

A new alliance CLOSING-THE-GAP-NOW held a historic first conference at the University of Minnesota in mid-November.  Our goal is to streamline medical oversight. I know it can be done.  Under Presidents Nixon and Ford I worked to replace rules that delayed and discouraged advances in transportation.

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We are ready to the same for modern medicine.  It is a moral imperative.  
Consider. Today when a patient is prescribed a so-called new cancer treatment,  it is actually the product of testing that left the laboratory as much as ten years before. That delay, the years and expense of testing, is the force driving up the costs of new therapies while denying them to patients. 

The result? Tragic stories like the recent, very public case of Brittany Maynard. Diagnosed with a brain tumor and given but a few months to live, she raised the issue of the right to die. Her story really should have us thinking about what patients need  to survive.

I know first hand how these lies of omission can deny hope and atrophy will to live.

I received the message that nothing can help in March 2009 when my wife contracted pancreatic cancer. Six weeks after I lost my wife, I heard that same message  in October 2009 when my daughter was diagnosed with brain cancer.

The problem is, what we were told was just not the case. 

In fact, there were a number of promising mainstream medical treatments in various stages of development. I found them for my family.  Those innovative treatments gave us a little more time together as a family, and time is precious when it is running out.

How can we offer these same opportunities to every cancer patient?

Let’s understand that the current system is a product of the sixties.  But there could be a better, faster and safer path.

Let’s harness the real power of new science, of big data, of the specificity of genome sequencing.  Let’s re-imagine a review process in which each patient would get the best option and the most advanced care. Then, using computing tools with Google-like power we can capture and share all the data from their experiences. Every patient could in-effect be part of a huge virtual clinical trial while getting the best personal care.

A deluge of new information could begin to be available in ten weeks instead of ten years. Patients would not be kept waiting when they simply have no time to wait. 

Thinking of tragic stories like Brittany Maynard’s,  it’s long past time to appreciate the value of medical innovation and how we can use it to value each and every human life by updating the procedures and regulations that are supposed to enhance care, not interfere. 

Morrissey is chair of the Scientific Advisory Board at the Richard M Schulze Family Foundation.

I’ve just returned from a visit to the UAE and Kuwait where I had the privilege of speaking with medicines regulators and pricing authority representatives from those two nations.

The topic of conversation was the value of innovation – and the urgency of rewarding it through timely approvals and appropriate pricing and reimbursement.

Our conversations ranged over many topics but focused specifically on a few key points:

* When patients have access to more effective medications, their overall health improves, even as their overall medical expenses go down. That, in turn, reduces national health-care spending and boosts the economy. Value must be measured in patient outcomes.

* Healthcare innovation saves lives, saves money, promotes economic growth, and provides hope for hundreds of millions of people (both patients and care-givers) in the United States and around the world.

* If we do not support the development of new medicines through timely licensing and fair pricing, innovation will be stopped in its tracks – and that is not an acceptable public health outcome.

* Regulators can be partners in innovation three ways: Through robust oversight, through active collaboration, and, most importantly, by being an innovation enabler.

We spent a lot of the conversation discussing the important differences between value and pricing – and that while both are important,  it is value that’s the higher priority since driving patient outcomes is the higher calling (and better long-term economic investment).

After all, as Yale economist William Nordhaus has written, "The social productivity of health care spending might be many times that of other spending.”

Insha'Allah.

CMPI

Center for Medicine in the Public Interest is a nonprofit, non-partisan organization promoting innovative solutions that advance medical progress, reduce health disparities, extend life and make health care more affordable, preventive and patient-centered. CMPI also provides the public, policymakers and the media a reliable source of independent scientific analysis on issues ranging from personalized medicine, food and drug safety, health care reform and comparative effectiveness.

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