Using the CATIE results as a baseline, Anirban Basu, PhD, David Meltzer, MD, PhD and Herb Meltzer, MD of Vanderbilt University estimate that such personalized research would be worth $342 billion over the next 20 years assuming that each additionally additional year of life free of schizophrenia is worth $50000. The authors note that this estimate does not take into account the ability to assign patients to treatment using more highly predictive algorithms that could raise the value even more. The value to more precisely establishing the cost-effectiveness of typical/atypical antipsychotics by more precisely establishing differences in patients â€“even in the absence of genetically based diagnostics is enormous. Considering that CATIE cost $42 million and is justified largely in terms of saving money for government, the CATIE results should not be considered definitive.
The study was sponsored by Best Practice, Inc. with partial support from the Foundation for Education and Research on Mental Illness, Janssen Pharmaceuticals, and the Center for Medicine in the Public Interest.
For full study results go to
And look under "Reports" for "Expected Value of Research on the Comparative Cost--effectiveness of Antipsychotics Drugs."